Chromogranin A Induces a Neurotoxic Phenotype in Brain Microglial Cells

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Hemin Induces the Activation of NLRP3 Inflammasome in N9 Microglial Cells

Background: Hemin is an important sterile component that induces a neuroinflammatory response after intracerebral hemorrhage, in which NLRP3 inflammasome activation has also proved to be involved. Although microglial activation acts as a key contributor in the neuroinflammatory response, the relationship between hemin and NLRP3 in microglia remains poorly understood. Objective: To investigate w...

متن کامل

P158: Targeting of Microglial M1/M2 Polarization Through Stem Cells Therapy as A Promising Candidate in Traumatic Brain Injury (TBI)

Traumatic brain injury is a serious global health problem with irreversible high morbidity and disability and Because of its unknown pathophysiological mechanisms, efficient therapeutic approaches to improve the poor outcome and long-term impairment of behavioral function are still remains lacking. The microglial cells are the resident macrophage cells of the brain and have M1/M2 phenotype, for...

متن کامل

Synergistic amplification of -amyloid- and interferon- -induced microglial neurotoxic response by the senile plaque component chromogranin A

Gilad Twig, Solomon A. Graf, Mark A. Messerli, Peter J. S. Smith, Seung H. Yoo, and Orian S. Shirihai Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston; BioCurrents Research Center, Program in Molecular Physiology, Marine Biological Laboratory, Woods Hole, Massachusetts; Department of Physiology, The Bruce Rappaport Faculty of Medicine, Techni...

متن کامل

P95: Targeting of Microglial M1/M2 Polarization through Stem Cells Therapy as a Promising Candidate in Traumatic Brain Injury (TBI)

Traumatic brain injury is a serious global health problem with irreversible high morbidity and disability and Because of its unknown pathophysiological mechanisms, efficient therapeutic approaches to improve the poor outcome and long-term impairment of behavioral function are still remains lacking. The microglial cells are the resident macrophage cells of the brain and have M1/M2 phenotype, for...

متن کامل

Human Microglial Cells Synthesize Albumin in Brain

Albumin, an abundant plasma protein with multifunctional properties, is mainly synthesized in the liver. Albumin has been implicated in Alzheimer's disease (AD) since it can bind to and transport amyloid beta (Abeta), the causative agent of AD; albumin is also a potent inhibitor of Abeta polymerization. Despite evidence of non-hepatic transcription of albumin in many tissues including kidney an...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1998

ISSN: 0021-9258

DOI: 10.1074/jbc.273.23.14339